研究成果

(2018-08-20更新)
  1. Yan Q, Zhao R, Shen C, Wang F, Li W, Gao SJ, Lu C*. Upregulation of miR-711 mediates HIV-1 Vpr promotion of KSHV latency and induction of pro-proliferative/survival cytokines by targeting the Notch/NF-κB signaling axis. J Virol. 2018 Jul 5. pii: JVI.00580-18. doi: 10.1128/JVI.00580-18. [Epub ahead of print]

  2. Li W, Hu M, Wang C, Lu H, Chen F, Xu J, Shang Y, Wang F, Qin J, Yan Q, Krueger B J, Renne R, Gao SJ, Lu C*. A viral microRNA downregulates metastasis suppressor CD82 and induces cell invasion and angiogenesis by activating the c-Met signaling. Oncogene. 2017 May 22. doi: 10.1038/onc.2017.139. [Epub ahead of print]

  3. Qin J, Li W, Gao SJ, Lu C*. KSHV microRNAs: Tricks of the Devil. Trends Microbiol,2017 Aug;25(8):648-661.

  4. Yan Q, Shen C, Qin J, Li W, Hu M, Lu H, Qin D, Zhu J, Gao SJ, Lu C*. HIV-1 Vpr Inhibits Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by Inducing MiR-942-5p and Activating NF-κB Signaling. J Virol, 2016; 90(19):8739-53

  5. Li W, Yan Q, Ding X, Shen C, Hu M, Zhu Y, Qin D, Lu H, Krueger BJ, Renne R, Gao SJ, Lu C*. The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA. PLoS Pathog. 2016 Apr 29;12(4):e1005605. doi: 10.1371/journal.ppat.1005605. eCollection 2016 Apr.

  6. Li W, Jia X, Shen C, Zhang M, Xu J, Shang Y, Zhu K, Hu M, Yan Q, Qin D, Lee MS, Zhu J, Lu H, Krueger BJ, Renne R, Gao SJ, Lu C*. A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway. Oncotarget. 2016 Apr 5. doi: 10.18632/oncotarget.8591. [Epub ahead of print]

  7. Yao S, Hu M, Hao T, Li W, Xue X, Xue M, Zhu X, Zhou F, Qin D, Yan Q*, Zhu J, Gao SJ, Lu C*. MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-κB signaling. Nucleic Acids Res. 2015 Oct 30;43(19):9362-78. doi: 10.1093/nar/gkv988. Epub 2015 Oct 7. [Epub ahead of print]

  8. Hu M, Wang C, Li W, Lu W, Bai Z, Qin D, Yan Q*, Zhu J, Krueger BJ, Renne R, Gao SJ, Lu C*. A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling. PLoS Pathog. 2015 Sep 24;11(9):e1005171. doi: 10.1371/journal.ppat.1005171. eCollection 2015 Sep.

  9. Xue M, Yao S, Hu M, Li W, Hao T, Zhou F, Zhu X, Lu H, Qin D, Yan Q*, Zhu J, Gao SJ, Lu C*. HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway. Nucleic Acids Res. 2014 Aug 7. pii: gku583. [Epub ahead of print]

  10. Yan Q, Ma X, Shen C, Cao X, Feng N, Qin D, Zeng Y, Zhu J, Gao S, Lu C*. Inhibition of Kaposi’s sarcoma-associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258. J Virol. 2014 May;88(9):4987-5000.

  11. Zhu X, Guo Y, Yao S, Yan Q, Xue M, Hao T, Zhou F, Zhu J, Qin D*, Lu C*. Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway. Oncogene. 2014 Apr 10;33(15):1986-96.

  12. Bai Z, Huang Y, Li W, Zhu Y, Jung JU, Lu C*, Gao SJ*. Genomewide Mapping and Screening of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) 3' Untranslated Regions Identify Bicistronic and Polycistronic Viral Transcripts as Frequent Targets of KSHV MicroRNAs. J Virol. 2014 Jan; 88(1): 377-92.

  13. Xue M, Guo Y, Yan Q, Qin D, Lu C*. Preparation and application of polyclonal antibodiesagainst KSHV v-cyclin. J Biomed Res. 2013 Sep; 27(5): 421-9.

  14. Yan Q, Li W, Tang Q, Yao S, Lv Z, Feng N, Ma X, Bai Z, Zeng Y, Qin D*, Lu C*. Cellular microRNAs 498 and 320d regulate herpes simplex virus 1 induction of Kaposi's sarcoma-associated herpesvirus lytic replication by targeting RTA. PLoS One. 2013; 8(2): e55832.

  15. Zhou F, Xue M, Qin D, Zhu X, Wang C, Zhu J, Hao T, Cheng L, Chen X, Bai Z, Feng N, Gao SJ, Lu C*. HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway. PLoS One. 2013; 8(1): e53145.

  16. Tang Q, Qin D, Lv Z, Zhu X, Ma X, Yan Q, Zeng Y, Guo Y, Feng N, Lu C*. Herpes simplex virus type 2 triggers reactivation of Kaposi's sarcoma-associated herpesvirus from latency and collaborates with HIV-1 Tat. PLoS One. 2012;7(2):e31652.

  17. Qin D, Feng N, Fan W, Ma X, Yan Q, Lv Z, Zeng Y, Zhu J, Lu C*. Activation of PI3K/AKT and ERK MAPK signal pathways is required for the induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1. BMC Microbiol. 2011 Oct 27;11:240.

  18. Zhu X, Zhou F, Qin D, Zeng Y, Lv Z, Yao S, Lu C*. Human immunodeficiency virus type 1 induces lytic cycle replication of Kaposi's-sarcoma-associated herpesvirus: role of Ras/c-Raf/MEK1/2, PI3K/AKT, and NF-κB signaling pathways. J Mol Biol. 2011 Jul 29; 410(5): 1035-51.

  19. Chen X, Cheng L, Jia X, Zeng Y, Yao S, Lv Z, Qin D, Fang X, Lei Y, Lu C*. Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice. Neoplasia. 2009 Dec; 11(12): 1272-84.

  20. Qin D, Zeng Y, Qian C, Huang Z, Lv Z, Cheng L, Yao S, Tang Q, Chen X, Lu C*. Induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1: involvement of IL-10 and IL-4. Cell Microbiol. 2008 Mar;10(3):713-28.

  21. Zeng Y, Zhang X, Huang Z, Cheng L, Yao S, Qin D, Chen X, Tang Q, Lv Z, Zhang L, Lu C*. Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling. J Virol. 2007 Mar; 81(5): 2401-17.

  22. Yao S, Tang Q, Cheng L, Zeng Y, Chen X, Qin D, Lv Z, Lu C*. Identification of B cell epitopes at the C-terminus of latency-associated nuclear protein of the kaposi's sarcoma-associated herpesvirus. Acta Virol. 2007; 51(2): 109-18.

  23. Qian C, Qin D, Tang Q, Zeng Y, Tang G, Lu C*. Identification of a B-cell antigenic epitope at the N-terminus of SARS-CoV M protein and characterization of monoclonal antibody against the protein. Virus Genes. 2006 Oct; 33(2): 147-56.

  24. Lu C*, Zeng Y, Huang Z, Huang L, Qian C, Tang G, Qin D. Human herpesvirus 6 activates lytic cycle replication of Kaposi’s sarcoma-associated herpesvirus. Am J Pathol. 2005 Jan; 166(1): 173-83.

  25. Lu C, Gordon GM, Chandran B, Nickoloff BJ, Foreman KE*. Human herpesvirus 8 reactivation and human immunodeficiency virus type 1 gp120. Arch Pathol Lab Med. 2002 Aug; 126(8): 941-6.